February 3, 2023 – Researchers have discovered a new class of compounds that selectively activate the human constitutive androstane receptor (CAR), offering a potential breakthrough in treating liver and metabolic diseases. https://doi.org/10.1021/acs.jmedchem.2c01140
Published in Journal of Medicinal Chemistry, the study highlights 3-(1H-1,2,3-triazol-4-yl)imidazo[1,2-a]pyridine derivatives that activate CAR at nanomolar levels without triggering the related pregnane X receptor (PXR), which is often associated with unwanted side effects. This discovery could enable safer, more targeted therapies by modulating key liver functions while avoiding off-target effects.
